Many papers have been published to the effect that plasmin, one of the proteolytic enzymes occurring in vivo by activation of plasminogen, breaks down plasma protein, increases capillary permeability, and is thus closely associated with the development of allergic symptoms, inflammation, hemorrhagic tendency, etc.
Experimental studies were performed in our Department on the antiphlogistic and antiallergic property of an antiplasmin agent, Resplamin, by administering it to 27 patients with exudative otitis media and other otorhinological diseases. The studies have led to the following conclusions.
1) Resplamin was remarkably effective in 8 of the 27 cases, effective in 9, fairly effective in 6, and ineffective in 4, the effective rate being 85.5%.
2) Aural and nasal discharge were positive for eosinophils in about one half of the cases of exudative otitis media getting the drug. The drug was effective in 83.3% of the cases of exudative otitis media. Concomitant infusion of the drug into the middle-ear cavity produced still better results.
3) In the other types of otorhinological diseases than the above, though the cases treated were small in number, the drug was found fairly good, and was thus evaluated worthy of tentative use.
4) Treatment with Resplamin of experimental acute otitis media and allergic otitis media in rabbits observed the middle-ear cavity of the treated animals to be not appreciably different from control, attesting to the potent antiphlogistic and antiallergic activity of Resplamin.