前庭神経外側核ニューロン活動に対するアセチルコリンおよびアトロピンの作用

抄録

Electrophysiological study was performed to determine the role of acetylcholine (ACh) on the vestibular transmission using iontophoresis method. Monosynaptic spike generation of lateral vestibular nucleus (LVN) neuron with vestibular nerve stimulation was blocked by iontophoretic application of atropine and GABA. In addition, iontophoretic ACh and glutamate produced an increase in spike firing of the monosynaptic neurons in the LVN. Atropine antagonized spike firing elevation with ACh unaffecting that with glutamate, however, GABA blocked both ACh- and glutamate-induced spikes. These results strongly suggest that ACh plays the role in neurotransmission from the vestibular nerve to the LVN monosynaptic neuron.