Hyperfunctioning thyroid nodules are very rare in Japan. We treated six patients with hyperfunctioning thyroid nodule from 1981 to 1984. All patient were females aged 9 to 52 years. Each patient had a palpable thyroid nodule, and the scintigram showed a hot nodule without hyperthyroidism. Five patients underwent thyroid lobectomy and one thyroid lobectomy with removal of the regional lymph nodes. Pathologically, four nodules were follicular adenoma, one was adenomatous thyroid hyperplasia and one chronic thyroiditis. The resected specimen in the last case contained adenomatous thyroid hyperplasia and follicular adenocarcinoma.