1988 年 81 巻 9 号 p. 1383-1387
The clinical usefulness of Tsumura-Saireito, which was judged by tympanoaudiometric tests, was compared with that of cepharanthin in 64 ears of 42 children with otitis media with effusion. The trial was a randomized controlled study.
The efficacy rate for the 32 ears treated with Tsumura-Saireito was 43.8% and that for the 32 ears treated with Cepharanthin was 18.8%; the difference was significant (p<0.05). No side effects were observed in either group.
These results indicate that Tsumura-Saireito is more effective in children with otitis media with effusion than Cepharanthin.