1989 年 82 巻 1 号 p. 133-138
Our previous reports dealt with tinnitus and impaired hearing as autonomic dysfunction in the field of otorhinolaryngology. In 46 patients, tinnitus without hearing loss or with impaired hearing of low-pitched sounds was the manifestation of autonomic dysfunction, as diagnosed by Schellong's test and T. M. I. These patients were treated orally with Tofisopam 150mg daily (50mg three times a day), and changes in the severity of tinnitus were monitored. The treatment was markedly effective or somewhat effective in 32 (70%) of the 46 patients. Schellong's test done at intervals of 2 weeks became negative in 70% of the 20 patients. These results indicate that Tofisopam is effective in the treatment of tinnitus.