ホスホマイシンの鼻粘膜繊毛運動への影響

抄録

The effect of fosfomycin on the nasal ciliary activity of the C₃H mouse was examined by a photo-electric method.
Ciliary activity was observed from 30 min to 24 hrs after incubation in RPMI-1640 including fosfomycin (1% to 5%). Ciliary activity was affected time- and dose-dependently. Investigation with several osmotic pressures suggested that the major impediment factor was osmotic pressure. Osmotic pressure of about 3, equivalent to 5% fosfomycin in water, did not severely affect the ciliary activity for at least 2 hrs after the incubation. Therefore, 5% fosfomycin in water is clinically advisable for in vivo concentration in consideration of dilution with nasal discharge and retention-time in the nasal cavity.