Abstract
The occurrence of drug-resistant bacteria such as MRSA is one of the major problems in the treatment of infectious diseases. The author evaluated the clinical and bacteriological effects of Norfloxacin (NFLX) in 23 patients with acute suppurative otitis media (AOM) or acute exacerbations of chronic suppurative otitis media (COM) from October 1986 to February 1987. A similar investigation was performed from October 1992 to February 1993, in 33 patients with AOM or COM, to determine whether NFLX-resistant bacteria have increased during the past 6 years. The clinical efficacy of NFLX was also examined in these patients and compared to that in the former study.
The frequencies of NFLX-sensitive bacteria in the former period were 95.5% for gram positive bacteria and 83.3% for gram negative ones. In the latter period the figures were 94.4% and 100%, respectively; i. e., no significant difference between the two periods.
The clinical efficacy rate for suppurative otitis media in the former study was 72.0% and in the latter 80.0%. The difference was not significant.
It appears that the antibacterial activity of NFLX has remained unchanged during the past 6 years.
