Abstract
The influence of three kinds of otic solution, NY-198 (Lomefloxacin), OFLX, and CMX on the mucociliary system of the tubotympanum in the guinea pig was examined. Culture medium RPMI 1640 was used as control solution in this study. The following results were obtained.
1. The otic solution, NY-198 did not injure the ciliary activity of cultured eustachian tube mucosa.
2. Intratympanic injection of the otic solution, NY-198 did not injure the ciliary activity or the mucociliary clearance in the tubotympanum in the guinea pig.
3. The other otic solutions, OFLX and CMX did not show any dramatic pathological effect on the mucociliary system of the tubotympanum. However, their effects were more prominent than those of the NY-198 solution.
In conclusion, the study showed that NY-198 otic solution had no pathological effects on the mucociliary system of the tubotympanum, and that NY-198 is an extremely safe otic solution for the treatment of bacterial otitis media.
