In this report, we present the outline of anti-vibration design technology of large merchant ship superstructures in recent years. First, the vibration mode characteristics of mega container ship superstructure are shown. Next, effectiveness of the vibration response analysis using whole ship model in order to evaluate the vibration response of superstructures at the early design stage is explained. The modeling technique of whole ship model focusing on superstructure and main engine, and the application technique of main engine exciting forces are introduced. Finally, research and development points to improve the accuracy of analysis regarding the influence of mesh size and the damping modeling technique are shown.