The yield strength and work hardening of Al-Mg-Si alloys are related to the concentration of solute atoms. This study was carried out to clarify the effect of two kinds of solute atoms on these properties in terms of a linear combination of contributions from a solid solution. Tensile tests were conducted with Al and with Al-0.62Mg-0.32Si, Al-0.65Mg-0.81Si, Al-2.4Mg and Al-4.4Mg (mass%) alloys in solid solution. Work hardening was analysed using the Kocks–Mecking model, yielding two parameters which indicate the storage and recovery of dislocations in the material. The yield strength could not be expressed as a linear combination of solute atom concentrations, but the amount of dislocation storage and dynamic recovery could be expressed as such linear combinations. In the high-strain region, the Kocks–Mecking model no longer applies, and the maximum stress at which the model failed increased with increasing concentrations of solute atoms. It is generally known that an interaction between strain fields around solute atoms and quenched-in vacancies can affect the yield strength owing to dislocation motion and that these atoms can retard the development of microstructure in high-strain regions. A linear combination of contributions from solid solutions is possible only for the storage and recovery of dislocations in the low-strain region.