A 38-year-old man complained of headache and nausea after traveling by aeroplane. On physical examination, high fever and nuchal rigidity were found. Computed tomography showed pneumocephalus. Magnetic resonance imaging showed sphenoid sinusitis. Cerebrospinal fluid examination revealed purulent meningitis. The patient was medically treated using antibiotic agents. The pneumocephalus disappeared and the purulent meningitis was resolved. We suggest that the barotrauma resulted in the pneumocephalus and purulent meningitis. Barotrauma is a potential cause of pneumocephalus, especially if the patient has parasinusitis.