Two cases of severe gastrointestinal hemorrhage caused by cytomegalovirus (CMV) infection are reported. Case 1: The patient had massive hematochezia caused by a CMV infection of the stomach and ileocecal region during steroid therapy for the treatment of interstitial cystitis. Surgery and the intra-arterial pitressin stopped the hemorrhage, but the patient subsequently died due to multiple organ failure. Case 2: While undergoing postoperative chemotherapy for a tumor of the testis, the patient developed Candida sepsis as a result of agranulocytosis, whereupon massive diarrhea and hematochezia occurred because of a CMV infection of the duodenum. Surgery, however, stopped the hemorrhaging, and the patient recovered favorably and was released from the hospital. CMV is liable to cause increased pathological changes in the gastrointestinal tract, and this should be anticipated even by those in the field of emergency and critical care medicine. Hence, it is necessary to be knowledgeable about CMV infections so that a precise diagnosis can be made.
