The growth and imperfection of the organic crystals are discussed in relation with the shapes and the binding forces. It is shown that the X-ray topography is the most suitable method for the observation of the lattice defects in the organic crystals compared with the optical or electron microscopic observations. The character of the dislocations are determined by the steric hindrances on the slip planes and also by the elastic energies of the dislocation lines. The X-ray topograpic observations of the crystals of long chain molecules, hexamethylbenzene, tetraoxane and three kinds of amino acids are shown. In these crystals, some of the dislocations with short Burgers vector are not observed. It is explained by the steric hindrances on the slip planes.