計量生物学
Online ISSN : 2185-6494
Print ISSN : 0918-4430
ISSN-L : 0918-4430
原著
An Extended Minimization Method to Assure Similar Means of Continuous Prognostic Variables between Treatment Groups
Tsugio NishiAtsushi Takaichi
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ジャーナル フリー

2003 年 24 巻 2 号 p. 43-55

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We propose a new treatment allocation method that assures similar means of continuous prognostic variables between treatment groups in randomized clinical trials. This method is an extension of the minimization method proposed by Pocock and Simon to continuous variables case. There are several measures to be minimized simultaneously, and we make a linear combination comprised of these weighted measures. The sizes of these weights of measures must be determined before implementation of this method. We give some examples to illustrate the achievement of this method and a guideline for the weights.

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© 2003 The Biometric Society of Japan
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