日本計量生物学会25周年記念論文
生物統計学の社会的貢献：四半世紀の経験と今後の展開
生物統計学の社会的貢献：四半世紀の経験と今後の展開
疫学理論の発展と計量生物学
2007 年 28 巻 Special_Issue_1 号 p. S57-S62
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2007 年 28 巻 Special_Issue_1 号 p. S57-S62
In this paper, I will review recent development in epidemiologic theories. It is emphasized that case-control studies are considered to be based on a underlying hypothesized cohort. Thus, various control selection options have been developed as the selection from the population at risk in that hypothesized cohort.
As an example of the use of new epidemiologic designs, a case-control study of infant asthma is illustrated. It is a part of the SORA (Study on Respiratory Disease and Automobile Exhaust) project which is a complex of epidemiologic studies for infants, school children, and adults conducted by the Ministry of the Environment. In that study, a two-stage case-control design which is effcient both for rare exposure and rare disease is adopted.
