計量生物学
Online ISSN : 2185-6494
Print ISSN : 0918-4430
ISSN-L : 0918-4430
構造化仮説群の多重性制御法 2(Graphical Approach,固定順序法,Fallback法)
藤原 正和
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ジャーナル フリー

2015 年 36 巻 Special_Issue_2 号 p. S173-S190

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Multiple test procedures are often used in the analysis of clinical trials including multiple objectives. To control the familywise error rate in the strong sense, various powerful procedures for structured hypotheses have been developed. In this paper, we introduce the graphical approach based on Bonferroni-based closed test procedures. Using the graphical approach, one can discuss different test strategies with the clinical team and build the appropriate multiple test procedure for the given study objectives. We illustrate not only the property of the graphical approach but also how to perform it by using SAS or R. Moreover, fixed sequence procedure and fallback procedure are presented within the framework of the graphical approach.

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© 2015 日本計量生物学会
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