計量生物学
Online ISSN : 2185-6494
Print ISSN : 0918-4430
ISSN-L : 0918-4430
多重性制御の基礎理論(閉検定手順)
土居 正明
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ジャーナル フリー

2015 年 36 巻 Special_Issue_2 号 p. S99-S121

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For many clinical trials, including the confirmatory ones, it is usually required that the FWER should be strongly controlled. The closed testing procedure, which is proposed by Marcus et al. (1976), is a procedure for strongly controlling the FWER. It is widely used for many methods of multiplicity control, for example, Holm method, step-down Dunnett method, fixed sequence method, and gatekeeping methods, etc. This article addresses the fundamental theory of the closed testing procedure, including the proof of strongly controlling the FWER, and several examples. For introduction, Fisher’s protected LSD method is examined and improved.

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© 2015 日本計量生物学会
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