Our hospital is a comprehensive stroke center in Hachinohe, Aomori Prefecture, one of the prefectures where stroke mortality is the highest in Japan. Here we introduce five actions for neuroresuscitation, especially treatment of acute stroke. Our comprehensive stroke center has a 24-hour medical care system providing stroke hot-line. We have ward rehabilitation specialists for rehabilitation from acute stroke. We hold campaign for public education called “Stroke Fair,” and skill-up seminar courses about medical care of acute stroke for healthcare staff members called “ISLS/PSLS course.” In addition, we have been proactively performing endovascular therapy for the treatment of acute cerebral infarction, demonstrating favorite outcomes.