Abstract
We report a case with long-term imatinib therapy followed by surgical resection for peritoneal recurrence of GIST. A 72-year-old man had undergone the resection of small intestinal tumor 7 cm in size and histopathologically diagnosed as a leiomyosarcoma 17 years before. In an emergency with abdominal pain 10 years after surgery, abdominal computed tomography scan showed peritoneal tumor with 4.6×4.5 cm in size. A biopsy was performed, and immunohistochemistry of the tumor showed positive staining for c-kit and CD34. Immunohistological examination of the specimen 10 years before was again performed, and it was positive for both c-kit and CD34, so we diagnosed the peritoneal tumor as local recurrence of GIST. Imatinib therapy was started. After the response as stable disease continued for 54 months, surgical resection for recurrent lesions had been undergone. Imatinib therapy has been continued after surgical intervention, and there is no evidence of recurrence 36 months after the surgical intervention.
