日本食品化学学会誌
Online ISSN : 2189-6445
Print ISSN : 1341-2094
ISSN-L : 1341-2094
論文
田七人参の茎と葉のラットにおける 90 日間反復投与経口毒性試験
矢内 和博佐藤 和正山崎 直樹増田 修一木苗 直秀
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2016 年 23 巻 1 号 p. 27-36

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Tienchi ginseng tea (TGT) extract was prepared from the above-ground organs, stems and leaves of Tienchi ginseng. The active ingredient of that is ginsenosides of the saponin. The rhizome is used as crude drug, but the above ground part is treated as food. In order to study the subchronic toxicity of TGT extract, Crl:CD(SD) rats of both genders were administrated TGT extract dissolved by water for injection orally at concentrations of 0 (control group), 100, 300 and 1,000 mg/kg (b.w.) once a day consecutively for 91 days, and observation of general condition, recording of body weight and food consumption were carried out once a week, examination of hematology, blood coagulation and biochemistry, serum protein electrophoresis, measurement of organ weight, and pathology were performed after administration of TGT extract for 91 days after the inspection of urinalysis and ophthalmology at 13 weeks. There is no death case and the change of general conditions according to TGT extract through dosages for 91 days in male and female rats. In addition, the toxic change with TGT extract was not accepted in the inspection item mentioned above. From the above-mentioned result, the subchronic toxicity by TGT extract was considered to be no observable adverse effect level in rat.

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