Experimental Study of Systemic and Hepatic Hemodynamics and Oxygen Metabolism in Extrahepatic Obstructive Jaundice

Abstract

The systemic and hepatic hemodynamics and oxygen metabolism in extrahepatic obstructive jaundice were studied experimentally. Twelve dogs with jaundice 2 weeks after ligating and cutting off the choledochus were compared with 6 normal dogs. The findings in the dogs with jaundice were as follows: (1) Although the mean arterial pressure (106±11 mmHg) was similar to the control value, the cardiac index (124±28 ml/min·kg) was increased and the total peripheral resistance (0.85±0.23 mmHg·Emin·kg/ml) was decreased, indicating a hyperdynamic state.(2) The hepatic arterial blood flow (9.07±1.30 ml/min·kg) and portal venous blood flow (30.4±4.7 ml/min·kg) were increased.(3) Although the oxygen delivery to the liver (6.55±0.93 ml/min·kg) and the oxygen consumption in the liver (0.95±0.50 ml/min·kg) were both increased, the oxygen extraction ratio in the liver (14.5±7.3%) was similar to the control value.(4) The ratios of the oxygen delivery (29.7±6.2%) and consumption (27.1±17.3%) in the liver to the systemic oxygen delivery and consumption, respectively, were increased. Thus, the oxygen demand in the liver was increased under the condition of obstructive jaundice, suggesting its close relation to the hyperdynamic state.