日本衛生学雑誌
Online ISSN : 1882-6482
Print ISSN : 0021-5082
ISSN-L : 0021-5082
ミニ特集 環境発がんと衛生~ヒ素研究の視点から~
Arsenic (+3 Oxidation State) Methyltransferase(AS3MT)遺伝子多型と無機ヒ素のメチル化能力との関連
阿草 哲郎國頭 恭TUE Nguyen MinhLAN Vi Thi MaiMINH Tu BinhTRANG Pham Thi Kim藤原 純子竹下 治男高橋 真VIET Pham Hung田辺 信介岩田 久人
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2015 年 70 巻 3 号 p. 186-196

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Arsenic metabolism affects the susceptibility of humans to arsenic toxicity; therefore, clarification of the factors associated with individual variations in arsenic metabolism is an important task. Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation. In this review, we summarize studies conducted by us in Vietnam and by others on the association of AS3MT genetic polymorphisms with arsenic metabolism as well as human health effects. Most of the SNPs in AS3MT showed inconsistent results in terms of genotype-dependent differences in arsenic metabolism among the studies. However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step.

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© 2015 日本衛生学会
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