日本衛生学雑誌
Online ISSN : 1882-6482
Print ISSN : 0021-5082
ISSN-L : 0021-5082
ミニ特集 出生前から生涯にわたる健康を守るための概念DOHaDの実証研究up-to-date
高次脳機能の健康を阻害する幼少期の環境要因と遺伝要因
掛山 正心
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ジャーナル フリー

2018 年 73 巻 2 号 p. 110-114

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The brain and mind are not only determined genetically but are also nurtured by environmental stimuli in early life. However, the relationship between early life environment and phenotypes in adulthood remains elusive. Using the IntelliCage-based competition task for group-housed mice, we previously found that maternal exposure to a low dose of an environmental pollutant, dioxin, resulted in abnormal social behavior, that is, low competitive dominance, which is defined by decreased occupancy of limited resource sites under highly competitive circumstances. Although we were unable to identify which behavioral phenotype applies to abnormalities such as “human social nature”, we found signs of hypoactivation of the medial prefrontal cortex, as seen in patients with autism spectrum disorder. In addition, another model of environmental factors, repeated isolation during development, and that of genetic factors including mice with neuronal heterotopia, which refers to brain malformations resulting from deficits of neuronal migration, showed low competitive dominance. These results indicate that a constitutive approach to capture the neural network of the whole brain is necessary especially in cases where the temporal gap of causal relationships is large such as DOHaD.

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