Twenty three examinees were orally given 10mg/kg of α-phenyl-α-ethyl-glutarimide (glutethimide), which has a narcotic effect to the cerebral cortex and the brain stem reticular formation. Before and one hour following the intake of glutethimide, they were tested with the TAF test and cold pressure test (CPT) with brain-wave recording in the state of eye-closing and during the TAF test. Investigations were made on the relation between the lowering of activity-level of the cerebral cortex and the TAF, and resulted in the following conclusion.
1) As to the alpha wave in the state of eye-closing, there was no difference between before and after the intake of glutethimide.
2) The TAF-L lowered significantly after the intake of glutethimide. In group A (excellent in TAF), the TAF-L tended to lowering after the intake but with no significant difference, while in group B (fair in TAF) showed significant lowering after the intake.
3) The blocking of alpha wave during the TAF test increased clearly after the intake. In group A, the grade of alpha-blocking was small after the intake, while it was significantly large in group B.
4) CPT-swing degree became small after the intake, and the basal maximum blood pressure decreased significantly after the intake though it was maintained in physiological range.
These studies indicated that the TAF lowered in correspondence with the lowering of activity-level of the cerebral cortex, and in the inferior subjects in TAF the proportion occupied with control of the will is bigger than that in the excellent in TAF. It also suggested that the superiority or inferiority of TAF is connected not only with the activity-level of the cerebral cortex but also with the individually characteristic disposition including cooperative ability between the cerebral cortex and subcortex.