The Metabolism of ¹⁰⁹Cd Administered to Mice Previously Given an Oral Dose of Cadmium

Abstract

The absorption rate of ¹⁰⁹Cd administered to mice previously treated continuously with cadmium for 3, 8, 16, and 32 days.
The results were
(1) The 32-day group was the only one that showed a significant decrease in the absorption rate as compared to the control group.
(2) The uptake of ¹⁰⁹Cd in the mucosal epithelium of the small intestine of the 32-day group was significantly lower than that of the control group.
(3) Animals exposed for 16 and 32 days showed significant decrease in the average count of ¹⁰⁹Cd per gram of kidney when compared to the control animals.
(4) The 32-day group was the only group with a significant increase in its excretion rate when compared to the control group.