The effect of light on leucophores of an isolated scale from the wild-type medaka Oryzias latipes was investigated.Leucophores were directly exposed beneath a light source of 150 or 300 lux.Fully dispersed leucophores in a M/7.5 KC1 solution and fully aggregated leucophores in a physiological saline solution did not show any noticeable response under illumination except for a very active Brownian movement of leucosomes.On the other hand, leucophores aggregated under the effects of both a stimulant and an inhibitor of the adrenergic β-receptor, dispersed under illumination and this response was found to be reversible.From the above findings, it was concluded that light directly induces leucosome dispersion in leucophores without any mediation of the adrenergic β-receptor.