Abstract
The inhibition of squalene epoxidase by thiocarbamate derivative, naphthiomate T was investigated with microsomes from Candida albicans and rat liver. Squalene epoxidase was found to be much sensitive to naphthiomate T with C. albicans than with rat liver. Furthermore, the epoxidase inhibition of C. albicans microsomes showed a non-competitive kinetics with respect to the substrate squalene and was not antagonized by the addition of the soluble fraction (activating factor). There was no evidence for an irreversible nature in epoxidase inhibition of C. albicans.
