Nippon Ishinkin Gakkai Zasshi
Online ISSN : 1882-0476
Print ISSN : 0916-4804
ISSN-L : 0916-4804
Protection of Oral or Intestinal Candidiasis in Mice by Oral or Intragastric Administration of Herbal Food, Clove (Syzygium aromaticum)
Yuuki TaguchiHiroko IshibashiToshio TakizawaShigeharu InoueHideyo YamaguchiShigeru Abe
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2005 Volume 46 Issue 1 Pages 27-33


We examined the effect of a clove (Syzygium aromaticum) administered by two different routes on Candida albicans growth, using a murine oral candidiasis model. When the clove preparation was administered into the oral cavity of Candida-infected mice, their oral symptoms were improved and the number of viable Candida cells in the cavity was reduced. In contrast, when the clove preparation was administered intragastrically, oral symptoms were not improved, but viable cell numbers of Candida in the stomach and feces were decreased. These findings demonstrate that oral intake of an herbal food, clove, may suppress the overgrowth of C. albicans in the alimentary tract including the oral cavity.

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© The Japanese Society for Medical Mycology
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