17O標識水の第1相臨床試験：安全性および脳血流MRIの実現可能性に関する検討［大会長賞記録］

原田 太以佑; 工藤 與亮; 亀田 浩之; 佐藤 良太; 白猪 亨; 尾藤 良孝; 藤間 憲幸; 常田 慧徳; 野川 敏史; 前田 憲一郎; 林 宏至; 佐々木 真理

doi:10.2463/jjmrm.2018-1669

Scientific Exhibit Award of 46th Annual Meeting

Phase I study of ¹⁷O-labeled water : safety and feasibility study of indirect proton MRI for the evaluation of cerebral blood flow [Presidential Award Proceedings]

Taisuke HARADA, Kohsuke KUDO, Hiroyuki KAMEDA, Ryota SATO, Toru SHIRAI, Yoshitaka BITO, Noriyuki FUJIMA, Satonori TSUNETA, Toshifumi NOGAWA, Kenichiro MAEDA, Hiroshi HAYASHI, Makoto SASAKI

Author information

Taisuke HARADA
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
Kohsuke KUDO
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
Hiroyuki KAMEDA
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
Ryota SATO
Research and Development Group, Hitachi, Ltd.
Toru SHIRAI
Research and Development Group, Hitachi, Ltd.
Yoshitaka BITO
Healthcare Business Unit, Hitachi, Ltd.
Noriyuki FUJIMA
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
Satonori TSUNETA
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
Toshifumi NOGAWA
Department of Preventive Dentistry, Division of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University
Kenichiro MAEDA
Hokkaido University Hospital Clinical Research and Medical Innovation Center, Research and Development Division
Hiroshi HAYASHI
Hokkaido University Hospital Clinical Research and Medical Innovation Center, Research and Development Division
Makoto SASAKI
Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University

JOURNAL FREE ACCESS

2019 Volume 39 Issue 2 Pages 66-

DOI https://doi.org/10.2463/jjmrm.2018-1669

Details

Abstract

　Indirect proton MRI can be used for the measurement of ¹⁷O. We evaluated the safety and feasibility of ¹⁷O-labeled water. No adverse effects were seen, and the measured concentrations were proportional to the injection dose. ¹⁷O-labeled water may be used for safe tracer of blood flow.

Corresponding author

Register with J-STAGE for free!