抄録
Based on recent advances in tissue engineering, we have developed three individual therapeuticmethodologies for regeneration of periodontal defects. (1) Human cultured gingival epithelial cell sheets couldbe applied as a promising graft “material” to treatment of chronic desquamative gingivitis. (2) Cultured gingivaldermal substitute could contribute to accelerated recovery of vertical and horizontal gingival recession. (3)Cultured periosteal cell sheets, which are demonstrated to express osteogenic activity in vitro and in vivo animalstudies, could regenerate alveolar bone defects in combination with platelet-rich plasma and porous hydroxapatiteparticles. Finally, current and next-generation technology in tissue engineering and periodontal regenerative medicineshould be discussed.
