日本口腔外科学会雑誌
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
総説
口腔感染症に対する抗菌薬療法—新しい抗菌薬を中心に—
金子 明寛
著者情報
ジャーナル フリー

2010 年 56 巻 10 号 p. 546-552

詳細
抄録

In selecting antimicrobial agents for oral infections, antimicrobial agents are determined taking into account presumed pathogenic bacteria, inflammation severity, and backgrounds of patients such as underlying disease. When the infections are treated, effectiveness of the treatment is increased by examining pharmacokinetics (PK) and pharmacodynamics (PD) such as in vivo absorption, distribution, metabolism and excretion of the antimicrobial agents, and by giving antimicrobial chemotherapy based on the PK-PD theory.
The oral infections are polymicrobial infections with anaerobes and aerobes. The most common species isolated are Prevotella, Peptostreptococcus and Streptococcus.
In severe oral infections, beta-lactamase producing bacteria are often involved, and the frequency to detect anaerobes increases with severity of the cases. Beta-lactamase in Prevotella degrades penicillin derivatives and cephem derivatives including the third generation. Anti-inflammatory treatment to decrease the number of pathogenic bacteria in infection foci and appropriate antimicrobial chemotherapy based on the PK-PD theory improve therapeutic efficacy and inhibit emergence of drug resistant bacteria.

著者関連情報
© 2010 社団法人 日本口腔外科学会
前の記事 次の記事
feedback
Top