2013 Volume 59 Issue 6 Pages 417-421
Plasma cell cheilitis is a rare, benign, inflammatory disorder that is histologically characterized by a dense infiltration of plasma cells within the submucosa. It presents as a circumscribed lesion of the lip. The cause of plasma cell cheilitis is unknown, and the treatment of choice has not been established. We report a case of plasma cell cheilitis in a 59-year-old man who had a swollen and eroded area on his lips and responded well to intralesional steroid injections. Biopsy showed band-like plasma cell infiltration. A diagnosis of plasma cell cheilitis was made after excluding contact dermatitis, lichen planus, bacterial and fungal infections, and an extramedullary plasmacytoma as differential diagnoses. Dramatic improvement was observed after intralesional injections of corticosteroids. The lesion disappeared, and no recurrence has been observed during 5 years of follow-up.
