Reports on central giant cell granuloma （CGCG） arising in the mandible are relatively rare. We describe a 17-year-old boy with CGCG of the left mandible. The lesion was first noticed as a painless swelling. Orthopantomography showed a multilocular radiolucent lesion in the mandible. A computed tomographic scan showed that the mandible had expanded, and the cortical bone had thinned. A giant cell granuloma was suspected, and a biopsy was performed. The biopsy specimen histologically showed multiple granulomatous nodules associated with proliferation of fibroblasts and infiltration of macrophages, inflammatory cells, and numerous multinuclear giant cells.
Because of abnormal bleeding during the biopsy, we prepared an autologous blood transfusion and extirpated the lesion by an intraoral approach with the patient under general anesthesia. During operation, the bleeding volume was 1000 g, and autologous blood transfusion was performed. Reccurence of the lesion wasconfirmed 21 months after operation, and renucleation of the lesion was performed with the patient under general anesthesia. Recurrence of the lesion has not occurred as of 2 years after the second operation.
