日本口腔外科学会雑誌
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
症例報告
口腔粘膜に初発し急激に増悪して肺出血により死亡した尋常性天疱瘡の1例
佐久間 康輔長縄 拓哉片岡 利之宇田川 源奥山 淳史安藤 智博
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2016 年 62 巻 4 号 p. 189-193

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We report on a 54-year-old Japanese man who was referred to the Department of Oral and Maxillofacial Surgery with the symptoms of erosive stomatitis and ulcer on the upper and lower gingivae and bilateral buccal mucosae. Laboratory tests showed elevated levels of anti-desmoglein 1 and 3 antibodies. Although steroid therapy was advised under a diagnosis of pemphigus vulgaris to prevent exacerbation, only a topical steroid was applied to the oral mucosae because of the patient’s nonadherence to his medication. One month after the initial visit, dermal vesicles and erosion were reported on the entire body. An underlying neoplasm was not identified on whole body positron emission tomography imaging or gastrointestinal endoscopic examination. Pemphigus vulgaris was diagnosed on the basis of clinical, pathological, and laboratory findings. Medication therapy with prednisolone (50 mg/day) and topical steroid ointment were performed under hospitalization. The erosions were successfully treated with the steroid therapy. However, 14 days after receiving treatment during hospitalization, the patient died of pulmonary hemorrhage approximately 2 months after the initial visit.

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© 2016 社団法人 日本口腔外科学会
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