2019 Volume 65 Issue 4 Pages 257-262
Angioimmunoblastic T-cell lymphoma (AITL) is one of the subtypes of non-Hodgkin lymphoma. The neoplasm is characterized by aggressive, rapid growth and a poor prognosis. A standard treatment protocol has not been established. In our literature review, only one case of AITL of the head and neck was diagnosed. We report a case of AITL diagnosed by submandibular lymph node biopsy. A 74-year-old woman visited our department because of a swelling in submandibular region. Magnetic resonance imaging showed multiple lymphadenopathy in the bilateral submandibular region. Positron-emission tomography-computed tomography showed the abnormal uptake of FDG in lymph nodes of the entire body. A submandibular lymph node biopsy was performed, and AITL was diagnosed histopathologically. CHOP or Hyper-CVAD, which are standard treatments for non-Hodgkin lymphoma, were proposed, but were not accepted by the patient. Alternatively, anti-CCR4 antibody therapy was conducted, but resulted in poor control of the disease. Finally, palliative care was performed until the patient died of the disease.
