2019 Volume 65 Issue 6 Pages 412-418
Cytomegalovirus (CMV) is a member of the herpes virus family. Typically, CMV infections pass as a subclinical infection and seldom appear. Here, we report a case of stomatitis with CMV infection in a patient with anaplastic large cell lymphoma (ALCL) after allogeneic bone marrow transplantation (allo-BMT). A 30-year-old woman was given a diagnosis of ALCL in 2011; therefore, she underwent conditioning therapy, allo-BMT, and received immunosuppressive drugs. She had diarrhea, skin erythema, and stomatitis and was given a diagnosis of acute graft-versus-host-disease (GVHD). Accordingly, steroids were administered. Nevertheless, as stomatitis worsened, she was referred to our department. Clinical examination revealed erosion and ulceration on the tongue and buccal mucosa, resulting in the diagnosis of stomatitis with acute GVHD. The use of immunosuppressive drugs and local irrigation was continued. The results for CMV antigenemia and quantification assays were positive on post-BMT day 78. On suspecting stomatitis with CMV infection, a biopsy of the ulcer on the dorsum of the tongue was performed. The histopathological examination revealed stomatitis with CMV infection. Stomatitis was managed with valganciclovir, with no recurrence.
