2021 Volume 67 Issue 11 Pages 620-625
Amyloidosis is a rare disease characterized by the deposition of an insoluble fibrillar protein in various organs and classified into two categories: systemic and localized. In the oral and maxillofacial region, the occurrence sites of localized amyloidosis are the buccal mucosa, sublingual gland, lip, palate and tongue. We report a case of localized nodular amyloidosis in the sublingual gland and submucosa of the mouth floor. A 72-year-old woman presented a nodular mass in the left side of the floor of her mouth and was referred to our hospital for further examination and treatment. Intraoral examination showed an elastic-hard, well-circumscribed mass, covered with normal epithelium, measuring approximately 32 × 15 mm in size. The pathological diagnosis via biopsy was amyloidosis (AL amyloidosis of the Aλ type). We diagnosed localized amyloidosis, as examination data did not support a diagnosis of systemic amyloidosis and multiple myeloma. The mass was removed surgically under general anesthesia. Seventeen months have since passed, with no sign of recurrence.
