Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Experimental radiosensitizer therapy for malignant tumor transplanted to nude mice
(4) Radiosensitive effect of imidazole compounds for human mouth floor-tongue poor differentiated epidermoid carcinoma
Kazuo SAKAIZUMIShigeru SENUMAKazuhito SATOTetsuo NAGAIMasami FUJINOWataru TAKAKADO
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1986 Volume 32 Issue 11 Pages 1985-1989

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Abstract

We had demonstrated in the former investigation that the effectiveness of imidazole radiosensitizer that is misonidazole, dinitroimidazole ethanol and 5-methoxy carbonyl-2-methyl sulfinyl-1-methyl imidazole for Ehrlich solid carcinoma transplanted into nude and conventional mice.
In this study, we report the effectiveness of imidazole radiosensitizer for oral malignant tumor.
Methods and evaluation: Battelle Columbus Laboratories Protocol. Tumor: KB cell=human mouth floor-tongue poorly differentiated epidermoid carcinoma.
Tumors were transplanted to subcutaneous of the right thigh of each mouse.
Subjects: Male nude CD-1 (ICR) mice (10 weeks age, 20-25 body weight).
Radiosensitizer: misonidazole (MISO), dinitroimidazole ethanol (DNIE) and 5-methoxy carbonyl-2-methyl sulfinyl-1-methyl imidazole (KIH-3).
Radiation: 60Co 15 Gy local radiation. These radiosensitizers were administrated into the abdomen of the mice prior to 30 minutes of local irradiation.
Results: On KB cell of nude ICR mice, tumor reduction effect was evaluated on MISO 20 mg+60Co 15 Gy group, but tumor recurred after 4 days, therefore the sensitization effect was not evaluated.
Radiosensitization effect was evaluated DNIE 10 mg +60Co 15 Gy group. There is no effect in KIH-3 40 mg +60Co 15 Gy group.

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