Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Clinical study on the effect of Vitamin B compounds on immunological responses (Part 2)
Comparison of the effect in different term administrations
Yutaka SAKURABAJunichi TANAKAHiroto KIMURAKatsuyuki OHTSUKAKenya ANEZAKIHiroaki ITOUMitsugu SUZUKI
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1986 Volume 32 Issue 11 Pages 1996-2002

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Abstract

It has been reported in recent years that vitamin B compounds have an immunoregulatory effect. We evaluated the effects of a preparation containing vitamin B1, B6 and B12 and noted the lowered immunlogical functions could be improved by the concomitant administration of vitamin B compounds for chemotherapy, earlier as Part 1 of the study. In the present study, 4 cases were added for re-evaluation and the differences in the time of its continued administration were also examined.
Nine patients with oral cancer who had undergone the chemotherapy (CDDP, PEP and MMC) and radiotherapy were treated for two different durations of the daily administration of vitamin B compounds, i.e. a relatively short term of 1-2 weeks and a long term of 3-10 weeks in parallel with the chemotherapy and radiotherapy and in the other except for these therapies.
As the criterion of cell-mediated immunity, the PHA lymphocytes transformation and the rate of T-cells and B-cells were determined. Serum immunoglobulins (IgG, IgA and IgM) and IAP were also determined.
Both the PHA lymphocytes transformation and the levels of serum immunoglobulins were lowered after the chemotherapy and radiotherapy, but a tendency of improvement was observed in both groups having the long-term and the short-term administration of the vitamin B compounds. The degree of the improvement indicated no difference between the two groups under the long-term and the short-term administrations. Thus, the administration of vitamin B compounds in both the long-term and the short-term groups was confirmed to be able to suppress the tendency for decrease of humoral and cell-mediated immunity, which suggested the possible applicability of this preparation as the immunomodulator.

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