家兎口蓋粘膜創傷治癒時のリシルオキシダーゼ活性と病理組織所見について

抄録

The purpose of this paper is to investigate the mechanism of scar formation on the palate which can inhibit maxillary development after cleft palate surgery. After 4 types of operations (elevation of the mucoperiosteum, excision of the mucosa, excision of the periosteum, and excision of the mucoperiosteum) were carried out on rabbit palates, the healing processs was studied histologically and biochemically by measuring lysyl oxidase activity which is necessary for collagen cross-linking.
The results were as follows.
The lysyl oxidase activity increased sharply and peaked at 4 days after elevation of the mucoperiosteum or excision of the mucosa when fibroblast had histologically appeared in the wound.
On the other hand, the activity increased gradually up to 14 days after periosteum excision, or excision of the mucoperiosteum, showing histologically remodeling of the underlying bone.
The results suggest that it is very important to avoid periosteum injury and to decrease the wound area exposing the bone without the mucoperiosteum as much as possible for growth of the maxilla after cleft palate surgery.