口腔粘膜の多形滲出性紅斑の臨床的検討

抄録

Eight cases of erythema exudativum multiforme (EEM) with involvement of the oral mucosa are reported. The diagnosis was made on the basis of the total clinical picture, including differential diagnosis from herpetic gingivo-stomatitis, recurrent aphtha, pemphigus and pemphigoid. Five cases of moderate to severe EEM were treated with systemic corticosteroid; an initial dose of 1.0 to 3.0 mg/day of bethamethasone was administered for several days and then gradually reduced. Corticosteroid was given for 7 to 17 days (mean 11.6 days). This treatment appeared to be helpful in shortening the healing time of this self-limited disease (EEM). Other mild cases (3 cases) were treated with topical use of a steroid ointment and soothing mouthwashes. Seven cases had history of taking drugs such as cold medicine prior to onset. But the etiology of EEM is not yet obvious.