A case of buccal mucosal and maxillary tumor seemed to be radiation induced cancer

Abstract

A case of radiation-induced cancer was reported. A 46-year-old man developed buccal mucosal and maxillary cancer (squamous cell carcinoma) 19 years after external radiation therapy for buccal papilloma. Previous irradiation was ⁶⁰Co, 186.5 Gy. Latent period was 19 years, but 7 years after the irradiation osteomyelitis arose in the mandible. X-ray films of the mandible revealed an osteolytic and osteosclerotic lesion.
Conservative treatment of the osteomyelitis was not so effective. Partital resection of the mandible and resection of buccal scar tissue combined with reconstructive surgery of the cheek using a pectoralis major myocutaneous flap were performed in September, 1984. The histological examination of the resected specimen showed squamous cell carcinoma and the ultrastructural study on this case was further performed.
In spite of wide excision and intra-arterial chemotherapy combined with irradiation, the patient died of the carcinoma in October, 1986.