Experimental study on disseminated intravascular coagubtion (DIC)

II. Effects of aspirin on experimental DIC induced by endotoxin in rabbits

Abstract

We have prcviously reported that an experimental model of disseminated intravascular coagulation (DIC) could be induced by continuous infusion of endotoxin (ET) at a dose of 3mg/kg duriy 3 hours in rabbits.Using this model, the effects of aspirin (ASA) against DIC were examined. Our studies were made in control rabbits and rabbits pretreated with ASA injection.The animals were divided into 4 groups as the followings;
Group I (control group): ET (3mg/kg) infusion only.
Group II (ASA pretreated group): Intravenous injection of ASA (100mg/kg) followed by ET (3mg/kg) infusion.
Group III (ASA pretreated group): Intravenous injection of ASA (10mg/kg) followed by ET (3mg/kg) infusion.
Group IV (ASA pretreatcd group): Intravenous injection of ASA (1mg/kg) followed by ET (3mg/kg) infusion.
Tentative diagnostic criteria for experimental DIC were designed as DIC scoring system. DIC score was useful to determine the degree of DIC state (DIC score≥6 points) and evaluate the effects of ASA pretreatment against DIC. There sults of present study indicated that inhibition of development of DIC was neted in group III, IV. Group IV made the lowest score (2.2±1.6) in ASA pretreated groups.
From these results, we may conclude that low dose of ASA could be effective for prevention of DIC.