Studies of the penetration of Cefotetan (CTT) in oral tissues

Abstract

We studied Cefotetan (CTT) concentration of serum and oral tissues (cortical bone, alveolar bone, gingiva, hard plate mucosa, buccal mucosa, maxillary bone, tongue, mandibular bone, cancellous bone) in 29 patients and similar experiments in 30 rats, and the following results were obtained.
(1) In rats, CTT was administered in a dose of 40 mg/kg by intravenous injection.The highest concentration was obtained in hard plate mucosa and followed in gingiva, mandibular cortical bone, tongue, submandibular gland, mandibular bone and maxillary bone at 10 minutes after administration.
(2) In humans, CTT in a dose of 2 g was administered by intravenous injection.Among gingiva, alveolar bone and cortical bone, the highest concentration was observed in gingiva. Peak concentration in gingiva was 62.6% of the corresponding serum value.In alveolar bone and cortical bone, they were 14.5% and 10.4%.
(3) In cortical bone, as from 90 minutes after administration, no detectable cases were observed in measured 6 cases, therefore, it is assumed that CTT may be rapidly excreted from cortical bone in comparison with other tissues.
(4) On the bases of these results, it was concluded that CTT is a useful antibiotic for the treatment of oral infection.