1988 Volume 34 Issue 5 Pages 810-813
The variations of serum SCC levels before and after chemotherapy are investigated in 28 oral squamous cell carcinomas. The mean serum SCC levels before chemotherapy and 1 week after chemotherapy are shown as follows; “No Change (NC)” cases (1.92ng/ml→1.95ng/ml, n=10) did not change; however, “Complete Response (CR)” cases (2.31ng/ml→1.26 ng/ml, n=4) and “Partial Response (PR)” cases (3.06ng/ml 2.29ng/ml, n 14) markedly decreased after chemotherapy with a significant difference. The variation rates of serum SCC levels before and after chemotherapy are-38.5% in CR cases, -23.5% in PR cases and +25.2% in NC cases. These results show that serum SCC levels correspond with the change of tumor volume in patiens.
Therefore, it suggests that the changes of serum SCC levels before and after chemotherapy would predict the effectiveness of chemotherapy in oral cancer.
