A clinical report of a case of Osler's disease, with HLA immunogenetical investigation

Abstract

Osler's disease is characterized by the triangular features of teleangiectatic lesions, hemorrhagic tendency and inheritance.
Recently we experienced a case of this disease. The patient was a 50 year old woman who complained of oral bleeding, and we found other 6 patients in her family. We treated her surgically and she now has a good prognosis. We detected the relationship between Osler's disease and HLA (Human Leukocyte Antigen) locus. HLA typing was carried out by microcytotoxicity test. The haplotype A2 and B5 were found in 3 of 4 patients in this family.