Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Experimental study of allogeneic demineralized bone implants in mandibular bone defects
Especially, effect of periosteum
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1989 Volume 35 Issue 1 Pages 1-15


Demineralized bone matrix were placed as inlay in defects of rabbit mandibula, then periosteum of operation site of one group was abraded and replaced (Group A), and periosteum of another group was abraded and excised (Group B). 1, 2, 3, 4 and 8 weeks after operations, radiographic, histopathologic and CMA findings of two groups were evaluated.
1. By 1 week, resorption of demineralized bone matrix and beginning of bone repair were observed. There was no difference between Groups A and B.
2. By 2 weeks, active osteoconduction was observed. Periostial ossification was observed in Group A only.
3. By 3 weeks, active osteoconduction and good bone repair were observed, but Group A bone repair was more active.
4. By 4 weeks, all defects were filled with new bone, but new bone of Group A was more compact than Group B.
5. By 8 weeks, there was no difference between Group A and B. Bone repair and calcifi cation was completed and cortical bone and bone marrow were obseved.
Defects with periosteum showed quicker repair in first stage, but 8 weeks following there was no difference and good repair was observed in both groups.

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