1989 Volume 35 Issue 1 Pages 209-216
Multiple primary cancer was first reported by Billroth in 1889. Since then the number of these cases reported had increased year by year, but only a few oral multiple cancers were reported.
We treated two cases of oral multiple cancer. Case 1 was a 61 year old male and a synchronous case. He had two lesions of the right edge of the tongue (T3 NO MO) and the left retromolar region (T2 NO MO). Their histological types were both squamous cell carcinomas. The tumor of the retromolar region was excised under general anesthesia and that of the tongue was irradiated by Ra needle after radio-chemotherapy. Case 2 was a 72 year old female and a metachronous case. She had first squamous cell carcinoma of the right buccal mucosa (T2 NO MO) and radiochemotherapy followed by excision of the tumor under local anesthesia. But 3 months later, metastasis appeared in the right submandibular lymphnode and she was received radical neck dissection. Twenty-seven months later after discharge, she had S.C.C.of the right gingiva of upper molar region (T3 NO MO) and that was excised under general anesthesia. No recurrence was seen in either case at present.
In addition we reviewed the Japanese literature and found the occurrence was 31 of 2049 cases and 1. 51% in Japan. There were 13 cases of oral multiple cancer that were described in detail and included our 2 cases. Ten of 13 cases were male and average age was 53.8 years in male, 66. 3 years in female. Thirteen lesions (48%) appeared in the most popular site the tongue.