The effect of unilateral duct ligation on submandibular salivary glands was studied by autoradiography, angiography and the radioactive microsphere technique.
A. Ligated side:
After several days, ligation of the main secretory duct led to acute atrophy, degeneration and tissue necrosis; fibroblast and adenoepithelial prolifecation was noted in this region and labelled with 3H-thymidine. Blood vessels were dilated and congested, and blood flow was found to be increased.
At 14 days, glandular regeneration and blood flow levels were found to have decreased to about 85% of normal.
B. Non-ligated side:
No pathological changes were noted. At 2-3 days, acinar cells were labelled with 3Hthymidine; blood vessels were found to be dilated blood flow increased.