Pleomorphic adenoma occurs most frequently at the parotid gland in the major salivary gland and at the palate in the minor salivary gland. Reports of pleomorphic adenoma in the lip and the buccal mucosa are rare. Two cases of pleomorphic adenoma considered to have originated at the lip and the buccal mucosa are presented. The first was a 52-year-old male in whom tumor occurred in the upper lip. The second was a 43-year-old female with a tumor in the right buccal mucosa. The tumors were surgically removed and on pathological investigation were diagnosed as pleomorphic adenoma case. No recurrence has been reported in either.